Carson Wentz threw two touchdown passes and ran for another score to lead the Indianapolis Colts (3-4) to a rain-soaked 30-18 victory over the San Francisco 49ers (2-4).
The Colts overcame the wet conditions and an early nine-point deficit to win for the third time in four games following an 0-3 start to the season.
The 49ers dropped their fourth straight game and remained winless at home for more than a year since beating the Rams on Oct. 18, 2020, as the return of starting quarterback Jimmy Garoppolo failed to provide any spark on a wet night.
The Colts return to Lucas Oil Stadium for their next game on Sunday, Oct. 31 against AFC South-leading Tennessee Titans (5-2) at 1 p.m. ET.
Colts vs. 49ers highlights
Below is a recap of the Colts vs. 49ers game:
11:22 p.m. — The Colts defeated the San Francisco 49ers 30-18 in a rain-soaked road game.
11:18 p.m. — Colts safety Khari Willis intercepts 49ers quarterback Jimmy Garoppolo's pass.
11:12 p.m. — Colts quarterback Carson Wentz completes 28-yard pass to Michael Pittman Jr. for a touchdown. Extra point is good. Colts - 30, 49ers - 12. 2:49 remaining in the game.
11:05 p.m. — Colts cornerback Xavier Rhodes intercepts 49ers quarterback Jimmy Garoppolo's pass and steps out of bounds at the 49ers' 39-yard line.
10:58 p.m. — Colts kicker Michael Badgley makes 42-yard field goal. Colts - 23, 49ers - 18.
10:55 p.m. — Colts quarterback Carson Wentz runs for 16 yards on 2nd & 15 play with 9:40 remaining in the game.
10:46 p.m. — 49ers quarterback Jimmy Garoppolo completes pass to wide receiver Deebo Samuel for a 14-yard touchdown to start the fourth quarter. Two-point conversion fails in an attempt to tie the game. Colts - 20, 49ers - 18.
10:40 p.m. — Colts have the ball at their own 33-yard line for 3rd & 22 at the end of the third quarter. Colts - 20, 49ers - 12.
10:28 p.m. — Colts running back Jonathan Taylor scores touchdown on 5-yard run. Extra point is good. Colts - 20, 49ers - 12.
10:26 p.m. — Pass interference called on 49ers safety Jaquiski Tartt for Wentz's pass intended for Michael Pittman Jr. at the 49ers 5-yard line.
10:23 p.m. — 49ers quarterback Jimmy Garoppolo fumbles the ball on 3rd & 5, forced by Colts defensive end Al-Quadin Muhammad, and is recovered by Colts defensive end Kwity Paye.
10:14 p.m. — Colts running back Jonathan Taylor runs for 3 yards to complete 4th & 1. Colts punt the ball with 8:34 left in the third quarter.
10:02 p.m. — Colts start the second half with the ball.
9:57 p.m. — Rain, rain and more rain on the way for the Colts. vs. 49ers game, according to 13News meteorologist Sean Ash.
1st half stats
Colts quarterback Carson Wentz was 6-13 for 66 yards, one touchdown pass, as well as running another touchdown in himself.
Colts running back Jonathan Taylor had 11 carries for 74 yards, and Colts wide receiver Michael Pittman Jr. leads the team in receiving yards with one catch for 57 yards.
9:43 p.m. — Colts quarterback Carson Wentz fakes handoff to Jonathan Taylor and runs the ball into the end zone himself. Two-point conversion fails. Colts - 13, 49ers - 12.
9:36 p.m. — 49ers wide receiver Deebo Samuel catches pass, but Colts linebacker Darius Leonard causes the fumble. Colts take over at 49ers 28-yard line with 3 minutes remaining in the half.
9:21 p.m. — Colts running back Nyheim Hines drops wide-open pass on 3rd & 7. Colts punt to 49ers with 7:39 remaining in the half.
9:19 p.m. — Following multiple defensive stops, the Colts have the ball with 9:22 remaining in the half.
9:04 p.m. — Colts quarterback Carson Wentz fumbles the ball before getting sacked on 2nd & Goal. The play was initially ruled an interception.
9:01 p.m. — Colts at 49ers 4-yard line as first quarter ends. 49ers - 12, Colts - 7.
9:00 p.m. — Colts running back Jonathan Taylor runs for 33 yards to give Colts 1st & Goal with 0:44 remaining in the first quarter.
8:58 p.m. — Pass interference on 3rd & 10 gives Colts first down.
8:53 p.m. — 49ers kicker Joey Slye makes 56-yard field goal. 49ers - 12, Colts - 7.
8:45 p.m. — Colts quarterback Carson Wentz completes pass to tight end Mo Alie-Cox, who scores a touchdown. Extra point is good. 49ers - 9, Colts - 7.
8:43 p.m. — Colts quarterback Carson Wentz completes 57-yard pass to wide receiver Michael Pittman Jr. on 3rd & 11. Colts now in 49ers territory.
8:38 p.m. — 49ers kicker Joey Slye makes 34-yard field goal. 49ers - 9, Colts - 0.
8:33 p.m. — Colts running back Jonathan Taylor fumbles ball on first possession. 49ers have the ball on the Colts' 28-yard line.
8:28 p.m. — 49ers score touchdown in eight plays in 4 minutes, 48 seconds. Running back Elijah Mitchell runs 14 yards on the play to score the touchdown. Kicker Joey Slye misses the extra point. 49ers - 6, Colts - 0.
8:20 p.m. — The Colts won the toss and decided to defer. The 49ers will have the first possession of the game.
8 p.m. — The Colts will be playing without wide receiver T.Y. Hilton, among others.
7:55 p.m. — 13Sports' Taylor Tannebaum shares three keys to a Colts victory Sunday night.
7:50 p.m. — 13News meteorologist Sean Ash is forecasting lots of rain for the Colts vs. 49ers game on "Sunday Night Football." And no — Levi Stadium does not have a roof.
The Colts haven't lost to the 49ers since 2001.
49ers quarterback Jimmy Garoppolo is expected to return after missing one game with an injured right calf. Colts defensive tackle DeForest Buckner will play the 49ers for the first time since he was traded to the Colts before last season.