INDIANAPOLIS — The Indianapolis Colts will face Russell Wilson and the Seattle Seahawks at Lucas Oil Stadium in their first game of the 2021 NFL season.
The home opener will be on Sunday, Sept. 12 at 1 p.m.
The highlight of the schedule is a Christmas Day game in Arizona against Kyler Murray and the Cardinals. The game will kickoff at 8:15 p.m. EST and will air on NFL Network.
Including the Christmas game, the Colts are slated to play four games in primetime, including a Week 7 trip to San Francisco on NBC's Sunday Night Football, which can be seen live on Channel 13 on October 24.
Indianapolis will play under the lights in Baltimore on Monday Night Football in Week 5 (Oct. 11) and will host the Jets on Nov. 4 for a Thursday Night Football matchup in Week 9.
RELATED: NFL 2021 schedule released
The Colts' old nemesis Tom Brady and the Super Bowl champion Tampa Bay Buccaneers visit Lucas Oil Stadium in Week 12 (Nov. 28). Top overall draft pick Trevor Lawrence will lead the Jacksonville Jaguars into Indy in Week 10, then the Colts will travel to Jacksonville to close the season with an AFC South contest on Jan. 9, 2022.
Here's the full 2021 Indianapolis Colts schedule:
Week 1: Sept. 12 vs. Seattle Seahawks (1 p.m)
Week 2: Sept. 19: vs. Los Angeles Rams (1 p.m.)
Week 3: Sept. 26 at Tennessee Titans (1 p.m.)
Week 4: Oct. 3 at Miami Dolphins (1 p.m.)
Week 5: Oct. 11 at Baltimore Ravens (Monday Night Football, 8:15 p.m.)
Week 6: Oct. 17 vs. Houston Texans (1 p.m.)
Week 7: Oct. 24: at San Francisco 49ers (Sunday Night Football, 8:20 p.m. WTHR)
Week 8: Oct. 31 vs. Tennessee Titans (1 p.m.)
Week 9: Nov. 4 vs. New York Jets (Thursday Night Football, 8:20 p.m.)
Week 10: Nov. 14: vs. Jacksonville Jaguars (1 p.m.)
Week 11: Nov. 21 at Buffalo Bills (1 p.m.)
Week 12: Nov. 28: vs. Tampa Bay Buccaneers (1 p.m.)
Week 13: Dec. 5: at Houston Texans (1 p.m.)
Week 14: Dec. 12 BYE
Week 15: Dec. 18/19: vs. New England Patriots (TBD)
Week 16: Dec. 25: at Arizona Cardinals (8:15 p.m.)
Week 17: Jan. 2: vs. Las Vegas Raiders (1 p.m.)
Week 18: Jan. 9 at Jacksonville Jaguars (1 p.m.)
The Colts will play six playoff teams from the 2020 season (Baltimore Ravens, Buffalo Bills, Los Angeles Rams, Seattle Seahawks, Tampa Bay Buccaneers and Tennessee Titans).
The Colts also announced their preseason opponents, including a home game against Carolina and road trips to Detroit and Minnesota.
Single-game tickets go on sale Thursday, May 13 at 11 a.m. ET at Colts.com/Tickets or Ticketmaster.com.
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