INDIANAPOLIS — Jalen Hurts scored on a seven-yard touchdown run with 1:20 left to give the Eagles their first lead of the game as they rallied to beat the Colts 17-16.
Hurts' score capped off an 11-play, 75-yard drive for the Eagles, who trailed by 10 points at the start of the fourth quarter.
Jonathan Taylor ran 22 times for 84 yards and a touchdown in the loss for Indianapolis. Matt Ryan was 23-of-32 for 213 yards, including six completions to Michael Pittman Jr. for 75 yards.
Zaire Franklin had 12 tackles and a half-sack to lead the defense. Chase McLaughlin connected on three of four field goals, including a 51-yarder.
Hurts ran for 86 yards and the game-winning touchdown for the Eagles. He also threw for 190 yards and a score.
The Colts host Pittsburgh on Monday Night Football on Nov. 28. The Eagles return home to face the Green Bay Packers next Sunday on Sunday Night Football on Channel 13.
Follow all the action in our live Colts game blog:
3:53 p.m. - The Colts start their attempt at a game-winning drive at their own 25.
After an incompletion on first down, Matt Ryan connected with Parris Campbell for a 14-yard reception and a first down. He then threw to Deon Jackson for only a yard, but Jackson got out of bounds to stop the clock with 53 seconds remaining.
After an incompletion, the Colts face a third-and-9 at their own 40-yard line with 48 seconds to go. But Ryan was sacked, forcing Indianapolis to burn their final timeout before a fourth-and-16 that could decide the game.
Ryan was pressured again and threw short to Jackson, who was forced out of bounds. The ball goes back to the Eagles on downs and they kneeled out the clock.
3:47 p.m. - After a timeout, Jalen Hurts ran straight ahead from the shotgun, picking up a first down at the Colts' 6-yard line.
Miles Sanders was stopped for a short gain on first down and Indianapolis used their first timeout with 1:29 left in the half.
Hurts was wrapped up for a loss of three yards on second down by Bobby Okereke and Zaire Franklin. After the Colts' second timeout, the Eagles faced third-and-goal from the 7-yard line. Hurts ran untouched up the middle for the touchdown.
The extra point from Jake Elliott was good and the Eagles lead 17-16 with 1:20 left in the game.
3:46 p.m. - After the two-minute warning, the Eagles lined up in a sneak formation, but only tried to draw Indianapolis offsides. It didn't work and Philadelphia burned their second timeout with two minutes remaining.
3:40 p.m. - Zaire Franklin was flagged for pass interference on a third-and-2 play from the Eagles' 33-yard line. The penalty moved the ball to the Indianapolis 28-yard line.
On third-and-4 at the 11, Boston Scott ran for two yards, setting up a fourth-and-2 after the two-minute warning. Indianapolis still leads 16-10.
3:31 p.m. - Facing third-and-3, Matt Ryan completed a deep pass to Parris Campbell for 32 yards to the Eagles' 4-yard line. Three plays later, Ryan was sacked for a loss of 14 yards which brought Chase McLaughlin on for a 37-yard field goal attempt.
Replays appeared to show a missed face mask call that would have given the Colts a first down.
The kick was good and Indianapolis pushed their lead back to six at 16-10 with 4:42 left in the game.
3:26 p.m. - The Colts took the ball right back. Zaire Franklin knocked the ball free from A.J. Brown after Brown picked up an Eagles first down at the Colts' 32. Eric Johnson recovered the fumble to give the Colts possession.
3:24 p.m. - Jonathan Taylor appeared to pick up a first down on third-and-1 at midfield, but as he kept the pile moving for another six yards, he lost the ball. The fumble was recovered by the Eagles with 10:46 to play.
3:16 p.m. - After an offsides penalty kept an Eagles' drive alive at midfield, Jalen Hurts scrambled for 23 yards, then found Quez Watkins for a 22-yard touchdown, pulling Philadelphia within 13-10 early in the fourth quarter.
3:06 p.m. - The Colts drove to the Eagles' 32-yard line, but Chase McLaughlin's 50-yard field goal try missed wide right, leaving the score 13-3 in favor of Indianapolis with 35 seconds left in the third quarter.
2:59 p.m. - The Eagles matched the Colts' three-and-out and Indy again takes over their own 45-yard line after the punt.
2:53 p.m. - The Colts went three-and-out on the next possession, punting the ball back to Philadelphia. Matt Haack's kick went out of bounds at the 5, setting the Eagles up with a long field and Indianapolis leading 13-3.
2:48 p.m. - The Colts defense stiffened up again, forcing Hurts out of bounds for a six-yard loss on fourth-and-10 at the Indy 39. Indianapolis takes over possession at their 45-yard line with 8:56 to play in the third quarter.
2:39 p.m. - Yannick Ngakoue sacked Jalen Hurts on the first play of the second half, forcing a fumble that was recovered by Grover Stewart at the Eagles' 22-yard line.
But the Colts were forced to attempt a 36-yard field goal by Chase McLaughlin after a third-down catch by Parris Campbell was overturned on review. McLaughlin's kick was good and Indianapolis leads 13-3 early in the second half.
2:17 p.m. - The Eagles ran out the clock on the half. They will receive the second-half kickoff.
Jonathan Taylor ran 11 times for 64 yards in the first half, while Matt Ryan completed 11-of-14 passes for 76 yards. Michael Pittman Jr. led Indianapolis receivers with four catches for 44 yards.
Eagles quarterback Jalen Hurts completed 10-of-14 passes for 111 yards and ran seven times for 35 yards in the first half.
2:14 p.m. - Matt Ryan connected with Alec Pierce on a third-down pass which was just short of the first down marker, but set up a field goal try for Chase McLaughlin.
McLaughlin drilled the 51-yard try with 13 seconds left in the half and a 10-3 Indianapolis lead.
2:09 p.m. - The Colts forced a three-and-out, then used their second timeout of the half to stop the clock with 1:51 remaining before a Philadelphia punt.
Keke Coutee returned the punt to the Colts' 45-yard line with 1:43 left in the half.
2:01 p.m - Matt Haack booted a 59-yard punt, but it rolled through the end zone for a touchback. Philadelphia gets the ball back with 2:33 before halftime and all three timeouts remaining.
1:53 p.m. - The Eagles drove to the Colts' 2-yard line, but Indianapolis kept them out of the end zone, forcing a 22-yard field goal by Jake Elliott to cut the Indy lead to 7-3 with 4:50 to play before halftime.
1:38 p.m. - Jonathan Taylor opened the second quarter with an 11-yard run to the Colts' 21-yard line for a first down, but that was it for the Colts who punted the ball back to Philadelphia.
PHOTOS: Colts host Eagles at Lucas Oil Stadium
1:35 p.m. - Jonathan Taylor ran for no gain as time ran out in the first quarter and Indianapolis leading 7-0.
Taylor ran for 46 yards and a touchdown in the opening quarter. Matt Ryan was 4 of 5 for 34 yards in the quarter and Michael Pittman caught three passes for 38 yards.
1:33 p.m. - Philadelphia moved into Colts' territory on their second drive of the game, but penalties backed them up into a first-and-35. A sack of Jalen Hurts by Zaire Franklin and Yannick Ngakoue forced the Eagles' second punt of the game.
1:23 p.m. - The Colts went three-and-out on their next possession. Matt Haack punted 47 yards and the Eagles will start their next drive from their own 16.
1:18 p.m. - Philadelphia picked up a first down on their opening drive, but the Colts defense forced a punt. Keke Coutee had a little trouble getting a handle on the punt, but was able to return it eight yards to the Colts' 28-yard line.
1:03 p.m. - The Eagles won the coin toss and elected to defer. After a touchback, the Colts' offense starts the game at the 25-yard line.
After a pair of short gains, Matt Ryan found Michael Pittman for a 24-yard gain into Eagles' territory, then Jonathan Taylor ran 28 yards into the red zone.
Ryan picked up a first down on a sneak on third-and-1, then Taylor slammed into the end zone for a 7-0 Indianapolis lead. Taylor ran for 49 yards on the drive.
12:30 p.m. - 13Sports director Dave Calabro previews Sunday's game from the field at Lucas Oil Stadium:
11:45 a.m. - Colts inactive list for today's game includes former Eagles quarterback Nick Foles.
The Colts midseason changes eventually paid off with last week's win in Las Vegas. Today, they look to reach the .500 mark with their second win under interim coach Jeff Saturday as they host the Philadelphia Eagles. The Eagles started 8-0 but are coming off their first loss of the season.