Rafael Nadal made an early exit from Wimbledon for the third year in a row, and it was a 19-year-old player ranked 144th in the world that showed him the door.
Nick Krygios of Australia used 37 aces and pulled everything he had out of his bag of tricks to beat number-one ranked Nadal 7-6, 5-7, 7-6, 6-3 and move into the quarterfinals.
In just his second major and first Wimbledon, Krygios is the first player outside the top 100 to beat a number one since it happened to Jim Courier in 1992.
Fourth seed and seven-time champ Roger Federer ousted Tommy Robredo 6-1, 6-4, 6-4 to reach the quarterfinals. Fifth seed Stan Wawrinka also won his fourth-round match in straight sets, including two tiebreakers. Milos Raonic needed four sets to advance to the quarters.
In the women's bracket, Serena Williams was unable to compete with her sister Venus in their doubles match, causing them to withdraw three games in. Serena Williams looked out of sorts, unable to catch the ball when it was tossed to her and at times unable to serve. Wimbledon officials said after the match that Williams was suffering from a virus.
No. 3 seed and French Open runner-up Simona Halep dropped just three games in her fourth-round match. Halep has reached the quarterfinals at all three Grand Slams this year and is the only top-4 women's seed still left in the draw.
Sabine Lisicki was a 6-3, 4-6, 6-4 winner over Yaroslava Shvedova to earn a meeting with Halep.
Sixth seed Petra Kvitova defeated Barbora Zahlavova Strycova of the Czech Republic 6-1, 6-5 on Tuesday. Kvitova moves on to play 23rd seed Lucie Safarova in the semifinals.
Kvitova won this tournament in 2011. She's the only grand slam champion still playing since Maria Sharapova lost to Angelique Kerber in the fourth round today.