Alex Barlow scored a career-high 19 points to lead Butler to a 79-46 victory over DePaul on Thursday night.
Khyle Marshall added 18 points for Butler (13-16, 3-14 Big East) as the Bulldogs put an end to a season-high seven-game losing streak.
Brandon Young led DePaul (11-20, 3-15) with 24 points. The Blue Demons will end the Big East regular season with at least a share of last place for the sixth straight season.
DePaul finished 1 of 18 from 3-point range. Despite a game featuring the conference's bottom two teams, Butler dominated DePaul in every aspect. The Bulldogs opened the game with an 18-4 lead. Barlow scored eight points in the span and Marshall drove the lane for two uncontested dunks.
Butler outrebounded DePaul 46-29 for the game.
DePaul was held to a season-low scoring output in losing by its largest margin this season.
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