Madison Ristovski scored 17 points and Michigan never trailed, knocking off No. 22 Purdue on the road 65-49 Wednesday night.
Ristovski was 5 of 9 from the field for the Wolverines (12-5, 3-1 Big Ten), connecting on 3 of 5 from long-range.
Michigan jumped to an 8-0 lead in the opening minutes of the game. Purdue battled back to twice cut the lead to a point, but the Wolverines took control with an 18-8 run capped by a Ristovski jumper.
The Wolverines pushed the lead to 42-29 on a Ristovski layup just over four minutes into the second half.
Siera Thompson and Shannon Smith each contributed 12 points for the Wolverines and Cyesha Goree added eight points and 14 rebounds.
The Boilermakers (11-5, 1-3) shot just 30 percent from the field and were led by the 12-point effort of April Wilson. Liza Clemons added 10 points.
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