Senior center Mitch Patton recorded his fourth career double-double with 26 points and 10 boards, but IUPUI fell short in its 2013-14 season opener at Utah Valley, 74-66.
The lead traded hands six times early in the game before six straight points put UVU (1-0) ahead 21-14 midway through the first half. The hosts lead later grew to 33-23 when Nelson collected a steal and raced the other way for a transition basket with 2:16 left before halftime.
Ian Chiles and Marcellus Barksdale also scored in double figures for the Jaguars.
IUPUI returns home Tuesday night to host Evansville in their home opener.