Andrew Luck threw three second half touchdown passes to T.Y. Hilton to match Texas quarterback Case Keenum, who threw three first-half scoring passes, and rally the Colts to a 27-24 comeback win in Houston.
The first half ended with the Texans leading 21-3, and their head coach Gary Kubiak leaving the field on a stretcher.
The Texans didn't say what was wrong with Kubiak, but did say he didn't have a heart attack. The team said the 52-year-old coach, a former NFL quarterback who calls the team's plays, was conscious and was with his family as he was taken to the hospital.
"He had an episode; he was light-headed and dizzy," Houston general manager Rick Smith said. "He was evaluated by a number of specialists ... he is awake and coherent." Smith told NBC that he would no rule out Kubiak returning to work Monday.
With Kubiak gone from the sideline, Houston's offense managed one field goal in the second half.
Meanwhile, the Colts offense went to work.
Luck found T.Y. Hilton from 10 yards out with :05 to play in the third quarter. Their attempt at a two-point conversion pass failed, leaving the Colts 12 points down heading into the game's final 15 minutes.
After Houston missed a long field goal attempt, Luck struck from the air again, hitting Hilton, again, for a 58-yard score with 9:46 still to play.
Then Luck and Hilton hooked up for the go-ahead score with 4:00 to play from nine yards out. Luck found tight end Coby Fleener for the two-point conversion.
Texas kicker Randy Bullock tried a desperation 56 yard field as time expired, but it fell short. The miss was Bullock's third of the night.
Before those two touchdowns, the Colts offense could only manage a pair of field goals from Adam Vinatieri. The Colts recovered the ensuring kickoff on Vinatieri's first half kick, but replay officials over-ruled their call on the field gave the ball back to the Texans for one more drive before halftime.
Keenum connected in the left flat with Andre Johnson from the 5-yard-line to make it 21-3 at the half. It was their third scoring hookup of the half.
Houston received the opening kick off and went down the field and took a 7-0 lead on a 62-yard strike from Keenum to Johnson just :50 seconds into the game.
Indianapolis responded with a drive that ended with Vinatieri's first field attempt of the night, but the kick was blocked and the Colts came away empty.
With 4:22 left in the first quarter, Keenum found Johnson for their second touchdown - this time from 41 yards - to make the score 14-0.
After the Colts took the second half kickoff and drove to Vinatieri's second field goal, Texas drove to match that kick on its next possession.
The Associated Press contributed to this report.
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