Wednesday, May 22 2013 1:02 PM EDT2013-05-22 17:02:01 GMT
It's been 24 hours since news broke of a Federal Bureau of Investigation raid at the City-County Building confiscating files from the Indy Land Bank program. The federal investigation also led to the arrestMore >>
Mayor Ballard held a news conference this morning hoping to shine light on several significant construction projects going around the city this season. Instead, all anyone wanted to talk about was the federal investigation into the Land Bank program, what he knew, when and why he didn't say something sooner.More >>
Wednesday, May 22 2013 12:38 PM EDT2013-05-22 16:38:55 GMT
You paid for it. Now the question is, where is it? Tonight at 11:00 pm, 13 Investigates has discovered the State of Indiana has thousands of items classified as lost or missing. Some of it is stuff youMore >>
What is the state doing with a concert grand piano and a robotic deer? And why are these items - and others - missing?
Wednesday, May 22 2013 11:09 AM EDT2013-05-22 15:09:50 GMT
The Internal Revenue Service official at the center of the storm over the agency's targeting of conservative groups has told Congress she did nothing wrong and has invoked her constitutional right to notMore >>
The Internal Revenue Service official at the center of the storm over the agency's targeting of conservative groups has told Congress she did nothing wrong and has invoked her constitutional right to not answer lawmakers' questions.More >>
Wednesday, May 22 2013 10:56 AM EDT2013-05-22 14:56:01 GMT
Telemarketers are deploying new tactics to get your secret information - and all they have to do is get you to answer the phone. A call to a home phone this week showed up on the screen as "private name,More >>
Telemarketers are deploying new tactics to get your secret information - and all they have to do is get you to answer the phone.More >>
Wednesday, May 22 2013 10:55 AM EDT2013-05-22 14:55:33 GMT
Tiger Woods says the "fried chicken" comment from Sergio Garcia was hurtful and inappropriate. Two weeks after they verbally sparred at The Players Championship, Woods says it's time to move on. GarciaMore >>
Tiger Woods says the "fried chicken" comment from Sergio Garcia was hurtful and inappropriate. Two weeks after they verbally sparred at The Players Championship, Woods says it's time to move on.More >>
Wednesday, May 22 2013 10:46 AM EDT2013-05-22 14:46:45 GMT
In a community used to experiencing tornadoes, many in Moore, Oklahoma are in a state of shock. "This was the storm of storms," said Oklahoma City Mayor Mick Cornett. Monday's tornado was categorizedMore >>
The mayor of the Oklahoma City suburb battered by a monstrous tornado says he is pushing to require safe-room shelters in all new homes.More >>
Wednesday, May 22 2013 10:35 AM EDT2013-05-22 14:35:19 GMT
A $3.4 million grant from the Lilly Endowment will help place about 90 teachers in the Indianapolis Public Schools. Some $2 million of that grant to The Mind Trust will go toward adding 40 people to theMore >>
A $3.4 million grant from the Lilly Endowment will help place about 90 teachers in the Indianapolis Public Schools.More >>
Wednesday, May 22 2013 8:47 AM EDT2013-05-22 12:47:25 GMT
State police say troopers found a 92-year-old woman inside a Muncie home where methamphetamine was being produced.More >>
State police say troopers found a 92-year-old woman inside a Muncie home where methamphetamine was being produced.More >>
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SOURCE ChromaDex Corporation
- NR is a Newly Discovered Vitamin and is a Natural Metabolite of Niacin (Vitamin B3) -
- Found in Milk, NR is Linked to Numerous Health Benefits -
IRVINE, Calif., March 8, 2013 /PRNewswire/ -- ChromaDex Corporation® (OTCQB: CDXC), an innovative natural products company that provides proprietary, science-based solutions and ingredients to the dietary supplement, food & beverage, animal health, cosmetic and pharmaceutical industries, and marketer of its branded, patented pterostilbene, pTeroPure®, announced today it has licensed from Washington University exclusive worldwide patent rights related to the recently discovered vitamin, Nicotinamide Riboside (NR). The patent rights cover the use of NR for the prevention or treatment of neuropathies caused by axon degeneration.
Axon degeneration is a common feature of many neurological ailments including mechanical, chemical or thermal injury, herpes, diabetes, ischemia or stoke, amyotrophic lateral sclerosis (ALS), glaucoma, rheumatoid arthritis, lupus, AIDS and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease1. Axon degeneration can also be caused by chemotherapy induced neuropathy or "CIN". Symptoms of neuropathy include weakness, numbness, burning and tingling, as well as pain in arms, legs and/or feet which can be debilitating. Neuropathies affect more than 20 million of people in the U.S.
The license was developed from research by Jeffrey Milbrandt, M.D., Ph.D., a James S. McDonnell Professor and head of the Department of Genetics at Washington University School of Medicine in St. Louis. His studies have focused on nicotinamide adenine dinucleotide (NAD), of which NR is an important precursor.
Milbrandt commented, "NAD biology has gained added importance in recent years due to its central role in controlling the activity of sirtuins, enzymes that are linked to regulation of metabolism as well as longevity. Interest is increasing in the roles of NAD biosynthetic enzymes and their substrates, such as NR, in the pathophysiology and treatment of neuropathies and neurodegenerative diseases, diabetes, cancer and inflammation."
This is the third acquisition made by ChromaDex of worldwide patent rights associated with NR. In July 2012, the Company licensed from Dartmouth College exclusive rights to several patents related to NR that include rights for human uses of NR as well as methods to produce NR via fermentation of engineered yeast strains. In July 2011, ChromaDex licensed a patent from Cornell University for a method for synthesizing NR in a cost effective, commercially-viable manufacturing process for large scale production.
Frank Jaksch, CEO and founder of ChromaDex, stated, "The acquisition of the Washington University NR patent rights is an important addition to our growing patent portfolio pertaining to NR. We believe our ownership of these patent rights creates a significant and meaningful barrier to entry for would-be competitors in the NR market."
Mr. Jaksch continued, "With the recent favorable published research on the significant health benefits of NR and the anticipated, forthcoming published research studies from several prestigious universities and research institutes, we believe NR is poised to become one of our most successful and valuable patented and proprietary ingredients to date."
About Nicotinamide Riboside (NR):
Sometimes referred to as the "Miracle Molecule" or "Hidden Vitamin," NR is found naturally in trace amounts in milk and other foods and is a more potent version of Niacin (vitamin B3). The beneficial effects of NR in humans include increased fatty acid oxidation, mitochondrial activity, resistance to negative consequences of high-fat diets, protection against oxidative stress, prevention of peripheral neuropathy and blocking muscle degeneration.
Researchers have shown that NR enhances levels of NAD in the mitochondria of animals. NAD is arguably the most important cellular co-factor for fuel utilization and allows sugars, fats and proteins to be converted into energy. Mitochondria are thought to play a part in the aging process. It is hoped that by stimulating mitochondrial function with the NR molecule, scientists may see increased longevity as well as other health improvements. Groups worldwide continue seminal discoveries in providing evidence for unique properties of NR in neuroprotection, sirtuin activation, protection against weight gain on high fat diet and improvement of blood glucose and insulin sensitivity.
Findings from a recent study by Weill Cornell Medical College and the Ecole Polytechnique Federale de Lausanne, Switzerland researchers showed mice on a high-fat diet that were fed NR gained 60 percent less weight than mice eating the same high-fat diet without NR. Moreover, unlike the mice that were not fed NR, none of the NR-treated mice had indications that they were developing diabetes and they had improved energy and lower cholesterol levels, all without side effects. The Swiss researchers were quoted as saying the effects of NR on metabolism "are nothing short of astonishing."
ChromaDex, Inc. is an innovative natural products company that provides proprietary, science-based solutions and ingredients to the dietary supplement, food & beverage, animal health, cosmetic and pharmaceutical industries. ChromaDex's pipeline of proprietary products includes patented pTeroPure® pterostilbene, which was named the 2010 North American Most Promising Ingredient of the Year by the independent research company, Frost & Sullivan. The company has also launched ProC3G™, a natural black rice extract containing 35% cyanidin-3-glucoside; NutraGAC™, a Gac fruit powder; pteroberry™, a natural pterostilbene and organic berry blend; and is in the process of developing Nicotinamide Riboside (NR), a novel next-generation B-vitamin. All products are backed with extensive scientific research and intellectual property. For more information about our products, visit www.chromadex.com or call 949-600-9694.
About Washington University:
Washington University, established by special act of the Missouri General Assembly on February 22, 1853, is a private, research university located in St. Louis. The University's mission is to discover and disseminate knowledge, and protect the freedom of inquiry through research, teaching, and learning.
Any statements that are not historical facts contained in this release are forward-looking statements. Actual results may differ materially from those projected or implied in any forward-looking statements. Such statements involve risks and uncertainties, including but not limited to those relating to product and customer demand, market acceptance of our products, the effect of economic conditions both nationally and internationally, ability to protect our intellectual property rights, impact of any litigation or infringement actions brought against us, competition from other providers and products, risks in product development, our ability to raise capital to fund continuing operations, the ability to complete transactions, and other factors discussed from time to time in the Company's Securities and Exchange Commission filings. The Company undertakes no obligation to update or revise any forward-looking statement for events or circumstances after the date on which such statement is made except as required by law.
Tuesday, May 21 2013 9:37 PM EDT2013-05-22 01:37:26 GMT
A South Bend teenager who angered a judge by smirking during his sentencing for killing a 16-year-old boy has received the maximum time behind bars allowed under a plea agreement. St. Joseph SuperiorMore >>
A South Bend teenager who angered a judge by smirking during his sentencing for killing a 16-year-old boy has received the maximum time behind bars allowed under a plea agreement.More >>
Wednesday, May 22 2013 5:21 AM EDT2013-05-22 09:21:57 GMT
State health officials are urging people to be careful as they head for Indiana's lakes and other bodies of water for summer recreation. The Indiana State Department of Health this week issued a listMore >>
State health officials are urging people to be careful as they head for Indiana's lakes and other bodies of water for summer recreation.More >>
Tuesday, May 21 2013 6:50 PM EDT2013-05-21 22:50:23 GMT
The Federal Bureau of Investigation is searching offices at the Indianapolis City-County Building Tuesday. Several city employees have been arrested. The Department of Metropolitan Development DirectorMore >>
Two city employees and three others are accused of using a city program aimed at tackling the abandoned house problem and turning it into a money-making venture. The five face charges involving wire fraud and bribery.More >>
Tuesday, May 21 2013 10:52 PM EDT2013-05-22 02:52:29 GMT
We've seen the damage from Oklahoma, hundreds of homes leveled. You have also seen those that survived a direct hit did so in a storm shelter. Storms shelters have not caught on in Indiana like otherMore >>
Storm shelters haven't caught on in Indiana like in some states along Tornado Alley, but more Hoosiers are making the investment to keep their families safe.More >>
Wednesday, May 22 2013 4:24 AM EDT2013-05-22 08:24:20 GMT
Organizers of a summer camp for children of military families say the program will go on this summer at Indiana Dunes National Lakeshore despite losing federal funding. Operators of Indiana Operation:More >>
Organizers of a summer camp for children of military families say the program will go on this summer at Indiana Dunes National Lakeshore despite losing federal funding.More >>
Wednesday, May 22 2013 4:22 AM EDT2013-05-22 08:22:57 GMT
The U.S. Environmental Protection Agency wants to add three Superfund sites in Indiana to its highest priority cleanup list for hazardous waste sites. The EPA proposed Tuesday adding Superfund sites inMore >>
The U.S. Environmental Protection Agency wants to add three Superfund sites in Indiana to its highest priority cleanup list for hazardous waste sites.More >>
Tuesday, May 21 2013 5:44 PM EDT2013-05-21 21:44:57 GMT
Cody Zeller's decision to leave Indiana University and head to the NBA looks like it may be paying off. Zeller's stock has gone up considerably after his performance last week at the NBA Combine in Chicago.More >>
Cody Zeller's decision to leave Indiana University and head to the NBA looks like it may be paying off.More >>
Tuesday, May 21 2013 9:01 PM EDT2013-05-22 01:01:00 GMT
Police arrested a semi driver with a blood-alcohol content more than three times the legal limit after a tip from a motorist in Grant County. State troopers monitoring a work zone on I-69 near the 271More >>
Police arrested a semi driver with a blood-alcohol content more than three times the legal limit after a tip from a motorist in Grant County.More >>
Wednesday, May 22 2013 7:47 AM EDT2013-05-22 11:47:04 GMT
After a quiet start to the week, things heat up today at the Indianapolis Motor Speedway with Community Day. And the track has a lot of family-friendly events planned. Community Day is a fan favoriteMore >>
After a quiet start to the week, things heat up today at the Indianapolis Motor Speedway with Community Day and a Pacers playoff game tonight. Threre are plenty of fan-friendly events planned for both.More >>