Doug McDermott had 25 points and nine rebounds, and No. 16 Creighton used a 19-4 run to break open a close game in the second half in a 79-66 victory over Indiana State on Saturday.
The Bluejays (14-1, 3-0) have won eight straight and are off to their best start in Missouri Valley Conference play since 2003-04.
The Sycamores (9-5, 2-1) lost for the 14th straight time in Omaha since 1999.
Gregory Echenique had 16 points and nine rebounds to just miss his fourth double-double in eight games. He scored inside to tie it 51-51 with 10 minutes left and gave the Bluejays the lead when he dunked Grant Gibbs' alley-oop pass.
Jake Odum and Manny Arop scored 13 points apiece and Justin Gant added 12 for the Sycamores, who made just 9 of 18 free throws in the second half.
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